| Bladder: |
| Gerard Apodaca, PhD | - Mechanotransduction
- Epithelial biology
- Urothelium
- Bladder
- Membrane traffic
| - Role of Piezo1 in bladder function
- UPK3a function during urinary tract development
- Localization of proteins in human urothelium
|
| Marcelo Carattino, PhD | - Acid-sensing ion channels (ASICs)
- Urothelial barrier
- Interstitial cystitis/bladder pain syndrome
- Mechanoreception and nociception
- Sensory neurons
| - Contribution of urinary K to the generation of interstitial cystitis symptoms (study in animal model of interstitial cystitis)
- Contribution of claudin-2 to interstitial cystitis/bladder pain syndrome (analysis of human samples)
- Characterization of a novel mouse model of interstitial cystitis (transgenic animal generated in our lab)
- Role of ASIC3 in the modulation of pain in a cyclophosphamide model of cystitis (study with ASIC3 knockout mice)
- Expression of ASIC3 in urinary bladder afferents
|
| Hypertension: |
| Cary Boyd-Shiwarski, MD, PhD | - Potassium Homeostasis
- WNK kinases
- Hypertension
- Kidney Transplant
| - Timecourse of WNK1 puncta formation and dissipation in mice after varying dietary potassium
- Tacrolimus induced WNK body formation in human kidney transplant recipients
- Effect of dietary potassium on ion transporters in the nephron
- Creation and characterization of L-WNK1-GFP cell line using CRISPR
|
| Manisha Jhamb, MD, MPH | - Health related quality of life
- Sleep apnea
- Depression
- Electronic Health record
- Hypertension
| - Physical functioning/health perceptions in CKD patients
- Sleep, fatigue and hypertension in SPRINT study
|
| Evan Ray, MD, PhD | - Hypertension
- Chronic kidney disease
- Extracellular volume status
- Ion channel electrophysiology
| - The influence of human genetic variants on ENaC activity
- A comparison of urinary protease enzyme levels with risk of developing hypertension and progression of chronic kidney disease
- A family with Liddle syndrome without mutations in the epithelial Na+ channel
|
| Aarohan Subramanya, MD | - Hypertension
- Potassium (Hyper- and Hypokalemia)
- WNK kinases
- Thiazide-sensitive NaCl Cotransporter (NCC)
- Loop diuretic-sensitive NKCC Cotransporter (NKCC)
| - Characterizing WNK signaling complexes in the transplanted kidney
- Effect of dietary potassium on the WNK-SPAK/OSR1 signaling pathway
- Identifying the molecular mechanism of Type 1 Bartter Syndrome
|
| Kidney Injury/Chronic Kidney Disease: |
| Manisha Jhamb, MD, MPH | - Health related quality of life
- Sleep apnea
- Depression
- Electronic Health record
- Hypertension
| - Physical functioning/health perceptions in CKD patients
- Sleep, fatigue and hypertension in SPRINT study
|
| Evan Ray, MD, PhD | - Hypertension
- Chronic kidney disease
- Extracellular volume status
- Ion channel electrophysiology
| - The influence of human genetic variants on ENaC activity
- A comparison of urinary protease enzyme levels with risk of developing hypertension and progression of chronic kidney disease
- A family with Liddle syndrome without mutations in the epithelial Na+ channel
|
Roderick Tan, MD, PhD
Lab website | - Acute kidney Injury
- Chronic kidney disease
- Proteinuria / Albuminuria
- Microvasculature / Endothelial Dysfunction
| - Effect of kidney-specific knockouts for MCP-1 on kidney disease
- Effect of nrf2 deletion on proteinuric kidney disease
- Evaluation of kidney microvasculature changes in individuals with AKI or CKD using contrast-enhanced ultrasound
|
| Steven Weisborg, MD, MSc | - Contrast nephropathy
- Acute kidney injury
| |
| Electrolyte Disorders: |
| Helbert Rondon, MD, MS | | |
| Public Health: |
| Manisha Jhamb, MD, MPH | - Health related quality of life
- Sleep apnea
- Depression
- Electronic Health record
- Hypertension
| - Physical functioning/health perceptions in CKD patients
- Sleep, fatigue and hypertension in SPRINT study
|
| Ion Channels: |
| Marcelo Carattino, PhD | - Acid-sensing ion channels (ASICs)
- Urothelial barrier
- Interstitial cystitis/bladder pain syndrome
- Mechanoreception and nociception
- Sensory neurons
| - Contribution of urinary K to the generation of interstitial cystitis symptoms (study in animal model of interstitial cystitis)
- Contribution of claudin-2 to interstitial cystitis/bladder pain syndrome (analysis of human samples)
- Characterization of a novel mouse model of interstitial cystitis (transgenic animal generated in our lab)
- Role of ASIC3 in the modulation of pain in a cyclophosphamide model of cystitis (study with ASIC3 knockout mice)
- Expression of ASIC3 in urinary bladder afferents
|
| Evan Ray, MD, PhD | - Hypertension
- Chronic kidney disease
- Extracellular volume status
- Ion channel electrophysiology
| - The influence of human genetic variants on ENaC activity
- A comparison of urinary protease enzyme levels with risk of developing hypertension and progression of chronic kidney disease
- A family with Liddle syndrome without mutations in the epithelial Na+ channel
|
| Tubule Physiology: |
| Shujie Shi, PhD | - ENaC
- Paraoxonase 2
- CCD cells
- Aldosterone
| - ENaC regulation by paraoxonase 2 in mousse CCD cells
|
| Marcelo Carattino, PhD | - Acid-sensing ion channels (ASICs)
- Urothelial barrier
- Interstitial cystitis/bladder pain syndrome
- Mechanoreception and nociception
- Sensory neurons
| - Contribution of urinary K to the generation of interstitial cystitis symptoms (study in animal model of interstitial cystitis)
- Contribution of claudin-2 to interstitial cystitis/bladder pain syndrome (analysis of human samples)
- Characterization of a novel mouse model of interstitial cystitis (transgenic animal generated in our lab)
- Role of ASIC3 in the modulation of pain in a cyclophosphamide model of cystitis (study with ASIC3 knockout mice)
- Expression of ASIC3 in urinary bladder afferents
|
| Ora Weisz, PhD | - Lowe syndrome/Dent disease
- Sickle cell disease/hemoglobin
- Megalin/cubilin
| - Impact of hemolysis and rhabdomyolysis on proximal tubule uptake of normally filtered ligands
- Transcriptional control of proximal tubule endocytic pathway capacity
- Etiology of Dent disease in mice models and CRISPR/Cas9 edited proximal tubule cell lines
- Using human stem cell organoids to study genetic diseases of the kidney
|
| Evan Ray, MD, PhD | - Hypertension
- Chronic kidney disease
- Extracellular volume status
- Ion channel electrophysiology
| - The influence of human genetic variants on ENaC activity
- A comparison of urinary protease enzyme levels with risk of developing hypertension and progression of chronic kidney disease
- A family with Liddle syndrome without mutations in the epithelial Na+ channel
|
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| Linda Fried, MD, MPH | | |
| Thomas Kleyman, MD | - Edema
- Hypertension
- Na and K transporters
- K sparing diuretics
- Proteases
- WNK kinases
- Mucins
| - Assessing expressing of urinary proteases by ELISA, and correlating with BP and weight
- Assessing functional properties of Na channel variants in an oocyte expression system
- Assessing the role of mucins in regulating the expression of ion transporters in epithelia
|
| Paul Palevsky, MD | | |
